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30px This page in a nutshell: Adrenaline, 0.3-0.5mg in adults, given intramuscularly, is the most important initial therapy.^[1] Peripheral venous catheter and IV fluids are needed for everyone with anaphylaxis.^[1] Oxygen saturation, pulse and blood pressure are monitored.^[1]

Indication^[1]	Medication^[1]	Route^[1]	Dosage^[1]		Time to effect^[1]	Repeat
Indication^[1]	Medication^[1]	Route^[1]	Adults	Children	Time to effect^[1]
Severe hives Labored breathing Hypotension Altered level of consciousness Severe abdominal pains and vomiting	Injection of adrenaline	Intramuscular in lateral thigh	0.3 - 0.5 mg	0.01 mg/kg, up to 0.5 mg 10-20kg: 0.15 mg ≥20kg: 0.3 mg	Less than 5 min	Every 5-10 min if needed
Asthma	Salbutamol (Ventolin) or own bronchodilator	Inhalation	5 mg Usually 4-6 doses	2-6 doses	Less than 5 min	Every 10 mins if needed
Hypoxia	Oxygen	Mask	>5 l/min		Almost immediate	Continuous
Altered level of consciousness or hypotension	Volume expander such as Ringer's	IV with pressure	20mg/kg		Fast	As needed
All anaphylaxis cases	Antihistamine such as desloratadine (Clarinex/Aerius)	Oral	10mg of desloratadine	<6 years: 2.5mg desloratadine 6 - 12 years: 5 mg desloratadine	Within 30-60 minutes
All anaphylaxis cases	Glucocorticoid such as betamethasone or cortisol	Oral or intravenous	5mg oral betamethasone or 8mg IV cortisol	<6 years: 3

References